Jose Mourinho will be without club captain and first-choice goalkeeper Iker Casillas (fractured hand) and so is expected to continue with January recruit Diego Lopez for Wednesday’s fixture.
Portugal centre-back Pepe returned after a month out with a substitute appearance against Sevilla on Saturday and is likely to start against Sir Alex Ferguson’s side.
Angel Di Maria (thigh) is ruled out for both legs but Jose Mourinho could have Xabi Alonso back after he returned to training this week.
Sir Alex Ferguson faced two fresh injury blows after beating Everton on Sunday, as Phil Jones (thigh) and Jonny Evans (knock) were forced off in the 2-0 win at Old Trafford.
Rio Ferdinand is likely to return to partner Nemanja Vidic at centre-back, while Robin van Persie should lead the visitors’ attack with Wayne Rooney deployed in a deeper midfield role.
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